While designing an armored vehicle platform, survivability is the most important capability and so protection design should be performed. In particular, mine protection design should be preferentially considered in a way that can reduce mass casualties. In this study, a simplified model, the main design parameters and their levels were defined, and then mine blast simulations were performed to obtain an effective protection design procedure. Before performing the main simulation, an experiment and simulation for a simple armor plate were performed and compared in order to certify the reliability of the numerical model. Afterwards, simulation cases, which were based on the reasonable numerical model, were defined by the DOE (Design of Experiment). An evaluation of the simulation results was carried out through both the contour and in a statistical manner, via a main effect analysis and ANOVA (Analysis of Variance). Finally, the impact characteristics of a protection parameters under the mine blast were estimated.